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Opana ER is a prescription medication that belongs to the medication referred to as opioid analgesics. Opana ER pills are generally prescribed for mild to intense pain in patients who require continuous opioid therapy for a prolonged length. Oxymorphone belongs to the group of drug called narcotic analgesics. As instructed by your healthcare professional, take this medication orally, usually once every 12 hours, without food (at least 1 hour before or 2 hours after eating). Take the tablets whole. Do not crush, break down chew, or crack them. The tablets should not be soaked in water, or licked, before being taken orally. Take one tablet at a time, and make sure you consume it whole with water. Talk with a healthcare professional about methods of reducing nausea if you’re experiencing it (such as resting down for one to two hours with as little head movement as possible). Opana medication may cause side effects such as dry mouth, stomach pain or swelling, nausea, vomiting, gas, excessive sweating, flushing, fast heartbeat, red eyes, headache, and feeling anxious or confused. Your health condition and reaction to treatment will decide the amount to be taken. Because using this medication regularly or for longer than advised can increase your chance of side effects, do not increase your dose. When directed, stop taking the drug as advised.