Vicodin 5-500 mg tablet contains a combination of acetaminophen and hydrocodone. This combination medication is used to relieve moderate to severe pain. Hydrocodone works in the brain to change how your body responds to pain. Acetaminophen can also reduce a fever. Acetaminophen is a less potent pain reliever that increases the effects of hydrocodone. Hydrocodone can slow or stop your breathing. Never use this medicine in larger amounts or for longer than prescribed. Never share Vicodin with another person, especially someone with a history of drug abuse or addiction. Keep the medicine safe where others can not get it. It can be harmful to others. Do not use Vicodin if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, or selegiline. Consult your doctor first, then take it as prescribed. You may take this drug with or without food. If you have nausea, it may help to take this drug with food. An overdose of acetaminophen can damage your liver or cause death. You should not use Vicodin if you are allergic to acetaminophen (Tylenol) or hydrocodone, or if you have recently used alcohol, sedatives, and tranquilizers.